Are you using colchicine for gout-flare prophylaxis?
Inflammation prophylaxis is a crucial component of the management of gout1
The clinical case for a 6-month course of inflammation prophylaxis with colchicine in chronic gout:
- Initiation of urate-lowering therapy may trigger breakthrough gout attacks with inflammation2
- Inflammation is a key hallmark of recurrent gout2
- In clinical studies, 6 months of inflammation prophylaxis with colchicine has been shown to prevent gout flares better than urate-lowering therapy alone1
Colchicine is thought to work by disrupting the gout inflammatory cascade in 2 key ways4
Colchicine blocks the inflammasome complex that mediates interleukin activation.4IL-1ß: Interleukin-1 beta.
By inhibiting polymerization of tubulin into microtubules, colchicine prevents neutrophil activation and migration to sites of inflammation.4