There’s more to
gout than

Gout is a chronic disease with a multifactorial pathogenesis1-4

Uric acid, renal function, and inflammation are often interconnected in gout

  • Acute gout flares may increase in frequency and duration and lead to the development of chronic gout1
  • Decreased kidney function is strongly associated with hyperuricemia2
Heyperglycemia and renal insufficiency leading to inflammation
Heyperglycemia and renal insufficiency leading to inflammation
  • In 90% of gout patients, hyperuricemia is related to inadequate renal excretion of uric acid3
  • Neutrophil-mediated inflammation may be a common link between chronic kidney diseases and gout4
Look beyond hyperuricemia in the management of gout

In chronic gout, inflammation can be a debilitating and consistent presence3

Immune-mediated inflammation drives gout pathology and symptoms

  • A key pathologic basis of gout symptoms is neutrophil influx into the joint fluid, which causes a release of inflammatory mediators5
  • Emerging data are showing that chronic inflammation may be present even in asymptomatic gout patients6
Inflammation leading to gout
Inflammation leading to gout

Chronic inflammation can have a devastating impact if left unaddressed

  • Persistent inflammation in gout can lead to chronic synovitis, bony erosion, cartilage damage, and tophi formation3
Inflammation can still persist—even when serum uric acid drops below normal baseline levels7